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This positive signal is further corroborated by another recent umbrella review, which highlighted that Coenzyme Q10 consistently demonstrates beneficial effects on cardiac function and clinical outcomes across meta-analyses ( 3.3 Emerging data in heart failure with preserved ejection fraction and endothelial function A 2022 phase II, double-blind, randomized trial in patients with preserved ejection fraction (HFpEF) reported that ubiquinol (600 mg/day), alone or combined with D-ribose, modestly enhanced LVEF and alleviated symptom burden, though exercise capacity improvements were inconsistent (Pierce et al., 2022)

Richard J Bloomer, Lesley C Tschume, Webb A Smith

European multicenter study on propionyl-L-carnitine in intermittent claudication

doi:10.1128/mBio.02481-14

Data collection and refinement statistics are summarized in Supplementary Table S1