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Vitamins and minerals act as enzymatic co-factors for hundreds of important enzymatic reactions in the body, so low levels of them can result in impaired metabolic functioning

Vitamin B12 typically requires different timing

Anticancer Res 5(1):130 Hosseini SA, Zaghari M, Lotfollahian H, Shivazad M, Moravaj H (2012) Reevaluation of methionine requirement based on performance and immune responses in broiler breeder hens

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While levodopa has all of these side effects, other PD medications might cause sleep difficulties and cognitive issues such disorientation and psychosis, MAO-B inhibitors, COMT inhibitors, and other similar drugs anticholinergic medications (Yuan et al., 2010)