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Top Genes Interacting with Lead According to the CTD platform [77], lead interacts with 3448 genes, with the highest number of interactions reported for TNF (Tumor Necrosis Factor), CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1), and CAT (Catalase), all of which are key players in inflammation and oxidative stress

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KEYNOTE-048: phase III study of first-line pembrolizumab (P) for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) [abstract LBA8_PR]

Although it has been proposed that this terminology is misleading and should be avoided 8 , it is also argued that these terms represent appropriate umbrella terms to describe overall mitochondrial health 9