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Insufficient concentrations of glutathione may increase the accumulation of ROS, including that of the highly reactive hydroxyl radical, which plays a key role in membrane lipid peroxidation and cellular structure damage [64]

Transport and subcellular localization of hydrogen peroxide In comparison to water, H 2 O 2 possesses a reduced membrane permeability, which is influenced by the phosphorylation and glycosylation states of membrane proteins, the lipid composition (lipid rafts) and osmotic stretching of lipid bilayers [1016]

These NPs can induce intracellular oxidative stress and cytotoxic effects, leading to DNA damage and the acquisition of an oncogenic phenotype

Beyond the Warburg effect: how do cancer cells regulate one-carbon metabolism

ISSN 0012-1630