glutathione in cells Quantification Live with Real-Time Imaging and Flow Cytometry Role of glutathione on cell

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staff at the Mass Spectrometry Resource Laboratory in the Center for Advanced Research Technologies (CART) and the Histology, Biochemistry, and Molecular Imaging (HBMI) Core at the Center for Musculoskeletal Research (CMSR) at URMC, the Proteomics/Metabolomics Core at Moffitt Cancer Center, which is funded in part by Moffitts Cancer Center Support Grant (P30CA076292), and University of Chicago Metabolomics Platform (RRID: SCR_022932)

Inhibiting Gln metabolism can impair SERCA activity by reducing intracellular GSH levels, which may lead to the increased expression of PD-L1

doi: 10.1016/0024-3205(89)90293-2 39

GCL-catalyzed conjugation of the -carbonyl group of glutamate with the amino moiety of cysteine is the rate-limiting step in glutathione synthesis