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Because they are not easily cleared, very high intakes can build up and cause toxicity

Pantothenic acid (B5) is the rate-limiting nutrient in the same cortisol pathway, and deficiency of either impairs adrenal output

Other Risk Factors : People with chronic alcoholism, those taking certain medications (like metformin or proton pump inhibitors), or individuals with specific genetic mutations affecting B12 metabolism may also benefit from B12 injections

In reality: * True neurodegenerative dementias such as Alzheimers disease are not reversed by B12

strongly evidence based but weakly reflected in practice