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Additionally, a randomized, double-blind, placebo-controlled trial in 162 elderly people (70 years) with mild vitamin B 12 deficiency found that vitamin B 12 supplementation for 24 weeks, alone or in combination with folic acid, did not improve memory performance (117)

Bulletin of Experimental Biology and Medicine (2016) 7

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GPX4 is required for repression of both canonical CASP1- and non-canonical CASP11-mediated cleavage of GSDMD 56 , indicating that GSH-dependent antioxidant systems do not only inhibit inflammasome assembly but also limit the oxidized membrane environment that favors gasdermin pore formation

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Figure 1 summarizes the timeline for discovery, biomarker investigations, and toxicokinetic studies for selected mycotoxins