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[12] In conclusion, G6PD deficiency is currently a common disorder in the world and extra attention should be paid to the areas and regions with high prevalence

The erythrocyte plasma membrane harbors a range of specialized transporters that form channels, carriers, or pumps to facilitate the passage of substrates

Although the pathogenesis of CD has not been fully elucidated, increasing evidence suggests that programmed cell death plays a key role in disease progression

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Dysregulation of KEAP1-NRF2 activity has been extensively demonstrated in cellular and animal models of ALS and in postmortem ALS motor cortex and spinal cord samples, so dysregulation of the NRF2/ARE antioxidant and cytoprotective pathway could be a possible mechanism underlying the progressive neurodegeneration in ALS and severity of the disease