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Refrigerate immediately once reconstituted, and use within 28 days

Kihara et al

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Although preclinical data are promising, clinical translation requires addressing NOs biphasic effects

and the main findings of ferroptosiss promotion/inhibition of immunogenic cell death, remodeling effect on the tumour microenvironment, and synergistic effect of combination therapy, as well as the limitations of the experimental model (e.g., lack of clinical verification) and unresolved scientific questions