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For instance, the pathogenic V122I variant of the protein transthyretin can induce cardiomyopathy due to destabilization of the transthyretin quaternary structure, i.e., the tetramer-folded monomer equilibrium, and an increased rate of tetramer dissociation [73]

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Since CMPK also has a lid domain 25 , we then tested whether JMF4073 is an inhibitor of CMPK

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