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Moreover, we validated the relationship between GSH-regulated replication stress and JMF4073 sensitivity in a number of TKI-insensitive human CML blast-crisis cells, and present the evidence of the synthetic lethality by targeting glutathione biosynthesis with JMF4073 in these cells

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Although not yet fully understood, the glutathione injections may interfere with the normal functioning of hormones that regulate metabolism which can result in weight gain

Exp Oncol 25:9397 Fanelli SL, Castro GD, De Toranzo EG, Castro JA (1998) Mechanisms of the preventive properties of some garlic components in the carbon tetrachloride-promoted oxidative stress