Abbreviations DUBs: Deubiquitinases GPX4: Glutathione peroxidase SLC7A11: Solute Carrier Family 7 Member 11 PROTACs: Proteolysis TArgeting Chimeras Ub: Ubiquitin FBXW7: F-box and WD repeat-domain containing 7 SOX9: SRY-box transcription factor 9 SOCS2: Suppressor of Cytokine Signaling 2 TRIM21: Tripartite Motif Containing 21 VDAC2: Voltage-dependent anion channel 2 SMURF2: Smad ubiquitination regulatory factor 2 cGAS: Cyclic GMP-AMP Synthase STING: Stimulator of Interferon Genes USP14: Ubiquitin specific peptidase 14 ALKBH5: AlkB homolog 5 NHEJ: Non-homologous end joining TRAF4: TNF receptor-associated factor 4 MCL-1: Myeloid cell leukemia-1 UBE2T: Ubiquitin-conjugating enzyme E2T FANCD2: FA group D2 protein H2Bub1: Monoubiquitylation of histone H2B SUPT16H: Suppressor of Ty homolog-16 EMT: Epithelial-mesenchymal transition OTUD5: OTU deubiquitinase 5 EZH2: Enhancer of zeste homolog 2 TNBC: Triple negative breast cancer KAP1: KRAB domain-associated protein 1 MDM2: Murine double minute 2 KLF5: Krppel-like factor 5 SENP: Sentrin-specific protease RUVBL1: RuvB-like protein 1 DTL: Dentideless IGF2BP2: Insulin-like growth factor 2 mRNA-binding protein 2 PTM: Post-translational modification NSCLC: Non-small cell lung cancer ESR1: Estrogen receptor CTH: Cystathionase CRLs: Cullin-RING complexes PDOs: Patient-derived organoids HRR: Homologous recombination repair NCTD: Norcantharidin HNSCC: Head and neck squamous cell carcinoma References Huang RX, Zhou PK
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