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J Cell Mol Med 2015;19:924-33

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Efficacy of a curcumin extract (curcugen) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study

The oxygen atoms in phenolic hydroxyl groups provide lone pair electrons to interact with positively charged metal ions, and the carbonyl oxygen atoms in the -diketone structure further enhance the stability of metal-curcumin complexes by providing additional coordination sites for metal ions (Moradi et al., 2020)