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In this regard, it is important to note that COX-2 inhibitors prevent ATL formation during leukocyte-endothelial cell interactions and by inflamed gastrointestinal tract of rats (Fiorucci et al., 2003)

132 Compositional expression of HIF1 also resulted in diminished immunostimulatory capacity of DCs, showing an increase in inhibitory mediators including IL10, inducible nitric oxide synthase and vascular endothelial growth factor (VEGF), which associated with a reduction in their ability to drive effector CD8 + T cell functions

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