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Vials should not be frozen, as freezing can compromise stopper integrity

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In a different network meta-analysis that included over 40,000 patients with atrial fibrillation and valvular heart disease, apixaban had a lower risk of major bleeding events compared with the other DOACs and warfarin

It depends on how bad your deficiency is and how you react to treatment

The most common effects include gastrointestinal disorders (nausea, stomach ache, indigestion, diarrhoea), especially in seniors, as well as allergic skin reactions such as rashes, redness, inflammation and itching, and in some cases even urticaria